私たちの研究室では遺伝子発現における翻訳のしくみやncRNAの機能などについて研究しています

研究業績

(国際学会)

Kurita, D., Miller, M.R., Muto, A., Buskirk, A.R. & Himeno, H.: Recognition of mRNA length on the ribosome by tmRNA and SmpB. Ribosomes Conference 2013, Napa Valley, California, July 9-12 (2013).

Goto, S., Muto, A., Himeno, H.:  Interplay of a GTPase and a ribosome-binding factor on the 30S subunit during a late stage of the bacterial ribosome biosynthesis.  The 9th International Conference on Ribosome Synthesis, Banff, August 22-26 (2012).

Himeno, H., Kurita, D. & Muto, A.: Molecular mechanism of trans-translation mediated by tmRNA/SmpB. IUMS2011 (International Union of Microbiological Societies 2011 Congress), Sapporo, September 6-16 (2011) (invited).

Kurita, D., Hattori, Y., Muto, A. & Himeno, H.: Molecular mechanism of the early stages of trans-translation by tmRNA/SmpB. RNA2011, Kyoto, June 14-18 (2011).

Goto, S., Muto, A. & Himeno, H. A GTPase dissociates a ribosome binding factor from the 30S subunit during a late stage of the bacterial ribosome biosynthesis. RNA2011, June 14-18, 2011, Kyoto, Japan (2011).

Tarusawa, T., Hase Y., Goto, S., Muto, A. & Himeno, H.: Loss of integrity of the ribosome confers salt-resistance on Escherichia coli cells. RNA2011, Kyoto, June 14-18 (2011).

Kurita, D., Une, M., Muto, A. & Himeno, H.: Molecular mechanism of the early stage of trans-translation. ISNAC2010 (37th International Symposium on Nucleic Acids Chemistry). Yokohama, November 10-12 (2010).

Kurita, D., Une, M., Muto, A. & Himeno, H.: Trans-translation by tmRNA/SmpB. The 3rd International Symposium on Protein Community. Nara, September 13-16 (2010).

Ushida, C., Hokii, Y., Sasano, Y., Sato, M., Sakamoto, H., Himeno, H., Muto, A., Fujiwara, T.: The mutation of the C. elegans genomic locus encoding a snoRNA has a defect in the pre-rRNA processing. RNA2010, Fifteenth Annual Meeting of the RNA Society, Seattle, June 22-26 (2010).

Kurita, D., Une, M., Muto, A., Himeno, H.: Molecular mimicry by tmRNA/SmpB during trans-translation. Ribosomes 2010 Meeting, page163, Orvieto, Italy, May 3-7 (2010)

Takemoto, C., Connell, S.R., Hase, Y., Naoe, C., Wang, H., Kaminishi, T., Kikuchi, T., Hirata, Y., Kurita, D., Muto, A., Muto, Y., Yokoyama, S., Himeno, H.: Structural studies for RsgA/YjeQ, a ribosome maturation factor. Ribosomes 2010 Meeting, page233, Orvieto, Italy, May 3-7 (2010)

Kurita, D., Une, M., Muto, A., Himeno, H.: Molecular mimicry of tRNA/mRNA during trans-translation. ASBMB 2010 Annual Meeting, page192, Anaheim, USA. April 24-28 (2010)

Kurita, D., Une, M., Muto, A. & Himeno, H.: Role of the C-terminal tail of SmpB during trans-translation. 23rd tRNA Workshop. Aveiro, Portugal, January 28-February 2 (2010).

Hase, Y., Yokoyama, S., Muto, A. & Himeno, H.: Removal of robosome small subunit-dependent GTPase confers salt resistance on Escherichia coli cells. 4th International Congress on Stress Responses in Biology and Medicine. Sapporo, October 6-10 (2009).

Une, M., Kurita, D., Muto, A. & Himeno, H.: Trans-translation by tmRNA and SmpB. 6th International Symposium on Nucleic Acids Chemistry. Takayama, September 27-October 1 (2009).

Hase, Y., Yokoyama, S., Kimura, T., Goto, S., Muto, A. & Himeno, H.: Physiological role of RsgA in ribosome biogenesis. 6th International Symposium on Nucleic Acids Chemistry. Takayama, September 27-October 1 (2009).

Kurita, D., Konno, T., Takada, K., Muto, A. & Himeno, H.: Molecular mimicry of tRNA+mRNA during trans-translation. 13th annual meeting of the RNA society, Berlin, July 28-August 3 (2008).

Kurita, D., Konno, T., Takada, K., Muto, A. & Himeno, H.: Interaction of SmpB with ribosome by directed hydroxyl radical probing. 22nd tRNA Workshop. Uppsala, November 1-6 (2007).

Kurita, D., Konno, T., Takada, K., Muto, A. & Himeno, H.: Molecular mechanism of trans-translation. 5th International Symposium on Nucleic Acids Chemistry. Tokyo, November 20-22 (2007).

Takada, K., Takemoto, C., Kawazoe, M., Shirouzu, M., Yokoyama, S., Muto, A. & Himeno, H.: Thermus thermophilus tmRNA and transtranslation. 5th International Symposium on Nucleic Acids Chemistry. Tokyo, November 20-22 (2007).

Kimura, T., Takagi, K. Hanawa-Suetsugu, K., Kalachnyuk, L., Muto, A. & Himeno, H.: Interaction between RsgA and the ribosome. 5th International Symposium on Nucleic Acids Chemistry. Tokyo, November 20-22 (2007).

Muto, A., Kurita, D., Sasaki, R. & Himeno, H.: Interaction between SmpB and ribosome from directed hydroxyl radical probing. Ribosomes 2007, Massachusetts, June 3-8 (2007).

Kurita, D., Konno, T., Takada, K., Asano, K., Muto, A. & Himeno, H. Trans-translation mediated by tmRNA and SmpB. RNA 2006 Izu “Functional RNAs and Regulatory Machinery”, Izu, December 3-7 (2006).

Murakami, T., Kimura, T., Okuno, T., Himeno, H. & Hashimoto, M.: Isolation, structure determination, and biological properties of cyclothiazomycins B1 and B2. ICOB-5 & ISCNP-25 IUPAC International conference on Biodiversity and Natural Products. Kyoto, July 23-28 (2006).

Takada, K., Takemoto, C., Kawazoe, M., Konno, T., Matsuta, N., Kurita, D., Shirouzu, M., Yokoyama, S., Muto, A. & Himeno, H. Functional analysis of factors involved in trans-translation. 4th International Symposium on Nucleic Acids Chemistry. Fukuoka, September 20-22 (2005).

Himeno, H., Hanawa-Suetsugu, K., Konno, T., Kurita, D. & Muto, A.: Enhancement of alanylation of tmRNA by SmpB. 2004 International Conference on Aminoacyl-tRNA Synthetase, Seoul, July 4-9 (2004).

Muto, A. & Himeno, H.: A novel GTPase activated by the small subunit of ribosome. International Conference in Honor of Kimitsuna Watanabe, Tokyo, June 3 (2004).

Konno, T., Takahashi, T., Muto, A. & Himeno, H. Various effects of paromomycin on tmRNA-directed trans-translation. RNA2003 Kyoto “The New Frontier of RNA Science”, Kyoto, November 24-27 (2003).

Okano, S., Nameki, N., Someya, T., Fujii, M., Terada, T., Shirouzu, M., Himeno, H., Muto, A., Inoue, Y., Shibata, T., Kuramitsu, S., Yokoyama, S. & Kawai, G. Interaction of tRNA-like domain of tmRNA and SmpB. RNA2003 Kyoto “The New Frontier of RNA Science”, Kyoto, November 24-27 (2003).

Takada, K., Hori-Takemoto, C., Kawazoe, M., Lee, S., Shirouzu, M., Yokoyama, S., Muto, A. & Himeno, H. In vitro analysis of the initial steps of trans-translation. The 3rd International Symposium on Nucleic Acid Chemistry, Sapporo, September 17-19 (2003).

Konno, T., Takahashi, T., Muto, A. & Himeno, H. Various effects of paromomycin on tmRNA-mediated trans-translation. The 3rd International Symposium on Nucleic Acid Chemistry, September 17-19 (2003).

Himeno, H., Hanawa-Suetsugu, K., Lee, S. & Muto, A.: The mechanism of trans-translation by tmRNA. 19th tRNA Workshop, Shanghai, April 6-11 (2002).

Muto, A., Fujihara, A., Tomatsu, H. & Himeno, H.: Physiological roles of tmRNA-mediated trans-translation in Bacillus subtilis. 19th tRNA Workshop, Shanghai, April 6-11 (2002).

G. Kawai,N. Nameki, H. Shirakura, H. Himeno & A. Muto: Structure of an RNA pseudoknot, PK1, of E. coli tmRNA. XIX International Conference on Magnetic Resonance in Biological Systems, Florence, Italy, August 20-25 (2000).

H. Himeno, N. Nameki, T. Tadaki, K. Hanawa, S. Lee, K. Ito, C. Ushida, B. Felden, J. F. Atkins, R.F. Gesteland & A. Muto: Structure and Function of E. coli tmRNA. 18th tRNA Workshop "tRNA 2000" Queens’ College, Cambridge, UK, April 8-12 (2000).

N. Nameki, P. Chattopadhyay, H. Himeno, A. Muto & G. Kawai: Structural characterization of an RNA pseudoknot of E. coli tmRNA involved in trans-translation. Tsukuba NMR '99. Tsukuba, October 18-19 (1999).

A. Muto, N. Nameki, T. Tadaki, K. Hanawa, M. Ishii, C. Ushida, B. Felden, J.F., Atkins, R.F., Gesteland, & H. Himeno: Structure and function of E. colitmRNA. RNA’99, pp435, Scotland, June 23-27 (1999).

H. Himeno, N. Nameki, T. Tadaki, K. Hanawa, M. Ishii, C. Ushida, B. Felden, J.F., Atkins, R.F., Gesteland, McCloskey, J.A., Crain, P.F. & A. Muto: Structure and function of E. coli tmRNA. The ribosome, pp45, Helsinger, Denmark, June 13-17 (1999).

N. Nameki, G. Kawai, Himeno, H. & Muto, A.: Conformational analysis of an RNA pseudoknot in tmRNA required for trans translation. 18th International Conference on Magnetic Resonance in Biological Systems. Hachioji, August 23-28 (1998).

A. Soma & H. Himeno: The recognition system of class II tRNAs. RNA'98, pp636, Madison, May 26-31 (1998).

H. Himeno, N. Nameki, T. Tadaki, M. Sato, K. Hanawa, M. Ishii, C. Ushida, B. Felden, J.F., Atkins, R.F., Gesteland & A. Muto: E. coli tmRNA in trans-translation. RNA'98, pp340, Madison, May 26-31 (1998).

B. Felden, K. Hanawa, J.F. Atkins, H. Himeno, A. Muto, R.F. Gesteland, J.A. McCloskey & P.F. Crain: Presence and location of modified nucleotides in E. coli tmRNA. Structural mimicry with tRNA acceptor branches. RNA'98, pp272, Madison, May 26-31 (1998).

B. Felden, N. Nameki, H. Himeno, A. Muto, J.F. Atkins & R.F. Gesteland: Structural organization of tmRNAs. RNA'97, pp226, Banff, May 27-June 1 (1997).

H. Himeno, M. Sato, T. Tadaki, M. Fukushima, K. Hanawa, M. Ishii, N. Nameki, C. Ushida & A. Muto: In vitro trans translation mediated by alanine-charged tmRNA. RNA'97, pp282, Banff, May 27-June 1 (1997).

A. Soma & H. Himeno: Identity determination of S. cerevisiae serine and leucine tRNAs. RNA'97, pp466, Banff, May 27-June 1 (1997).

H. Himeno, S. Yoshida & A. Soma: Identity determination of yeast class II tRNAs. 17th International tRNA workshop, 4-27, Kazusa, May 10-15 (1997).

A. Soma & H. Himeno: Cross-aminoacylation of class II tRNA between E. coli and yeast. 17th International tRNA workshop, 4-13, Kazusa, May 10-15 (1997).

H. Himeno, N. Nameki, T. Tadaki, M. Sato, K. Hanawa, M. Fukushima, M. Ishii, C. Ushida, A. Muto, B. Felden, J. MacCucheon, J.F. Atkins & R.F. Gesteland. A dual function of E. coli tmRNA (10Sa RNA) in trans-translation. 17th International tRNA workshop, 9-13, Kazusa, May 10-15 (1997).

Tadaki, T., Fukushima, M., Ushida, C., Himeno, H. & Muto, A.: Interaction of tmRNA with ribosomes in Escherichia coli. 17th International tRNA workshop, 9-27, Kazusa, May 10-15 (1997).

H. Himeno, A. Soma & S. Yoshida: Identity determination of Saccharomyces cerevisiae class II tRNAs. A Keystone Symposium, Aminoacyl-tRNA synthetases in biology and disease, pp54, Taos, New Mexico, February 1-6 (1997).

B. Felden, H. Himeno, A. Muto, J. F. Atkins and R. F. Gesteland: Evidence for a full tRNA mimicry in E. coli 10Sa RNA. Translational Control, pp86, Cold Spring Harbor, New York, Set 4-Sep 8 (1996).

H. Himeno, M. Sato, T. Tadaki, M. Fukushima, C. Ushida. and A. Muto: In vitro trans translation mediated by alanine-charged 10Sa RNA. Translational Control, pp305, Cold Spring Harbor, New York (1996).

H. Himeno, A. Soma, S. Yoshida and K. Nishikawa: Evolution of the recognition system of class II tRNAs. RNA'96, pp288, Madison, Wisconsin, May 28-June 2 (1996).

H. Himeno, M. Sato, T. Tadaki, M. Fukushima, C. Ushida. and A. Muto: Tag-peptide synthesis mediated by alanine-charged 10Sa RNA in vitro. RNA'96, pp289, Madison, Wisconsin, May 28-June 2 (1996).

A. Muto, H. Himeno, C. Ushida, J. Matsuno, T. Tadaki and M. Fukushima: Bacterial 10Sa RNA which interacts with 70S ribosome. Frontiers in translation, pp207, Victoria, Canada (1995).

H. Himeno, R. Kumagai, A. Soma, K. Nishikawa, H. Asahara, K. Tamura, N., Nameki, T. Hasegawa and M. Shimizu: Evolution of the recognition system of class II tRNAs. 16th International tRNA workshop, pp27, Madison, Wisconsin, May 27-June 1 (1995).

A. Muto, J. Matsuno, T. Tadaki, M. Fukushima, S. Sasamura, C. Ushida and H. Himeno: The structure and function of bacterial 10Sa RNAs. 16th International tRNA workshop, pp54, Madison, Wisconsin, May 27-June 1 (1995).

H. Asahara, H. Himeno, K. Tamura, N. Nameki, T. Hasegawa, and M. Shimizu: Identity switching among E. coli class II tRNAs. 16th International tRNA workshop, pp90, Madison, Wisconsin, May 27-June 1 (1995).

T. Hasegawa, T. Yokogawa, Y. Sano, H. Himeno and K. Nishikawa: Primary structure of E. coli proline tRNA and the recognition by prolyl-tRNA synthetase. 16th International tRNA workshop, pp136, Madison, Wisconsin, May 27-June 1 (1995).

A. Soma, R. Kumagai and H. Himeno: Recognition system of Saccharomyces cerevisiae tRNALeu. 16th International tRNA workshop, pp220, Madison, Wisconsin, May 27-June 1 (1995).

T. Suzuki, T. Ueda, H. Himeno, T. Yokogawa, K. Nishikawa and K. Watanabe: G33 of serine tRNAs works as a negative determinat toward leucyl-tRNA synthetase in the non-universal genetic code system of Candida species. 16th International tRNA workshop, pp228, Madison, Wisconsin, May 27-June 1 (1995).

K. Tamura, H. Himeno, H. Asahara, N. Nameki, T. Hasegawa, and M. Shimizu: Roles of the CCA end of tRNA in translational processes. 16th International tRNA workshop, pp232, Madison, Wisconsin, May 27-June 1 (1995).

H. Asahara, H. Himeno, K. Tamura, N. Nameki, T. Hasegawa and M. Shimizu: Discrimination among E. coli tRNAs with a long variable arm. Second International Symposium on Nucleic Acids Chemistry, pp207, Sapporo, November 9-11 (1993).

M. Shimizu, N. Nameki, H. Asahara, K. Tamura, H. Himeno and T. Hasegawa: Discrimination among E. coli tRNAs viewed from switching of tRNAVal to others
in vitro. 15th International tRNA workshop, pp106, Cap d'Agde, France, May 30-Jun 4 (1993).

T. Hasegawa, Y. Sano, H. Asahara, H. Himeno, K. Tamura, N. Nameki, K. Kimura and M. Shimizu: Recognition sites of E. coli proline tRNAs for prolyl-tRNA synthetase. 15th International tRNA workshop, pp290, Cap d'Agde, France, May 30-Jun 4 (1993).

H. Himeno, H. Asahara, K. Tamura, T. Hasegawa, K. Watanabe and M. Shimizu: Discrimination between class II tRNAs. 15th International tRNA workshop, pp291, Cap d'Agde, France, May 30-Jun 4 (1993).

H. Himeno, T. H. Asahara, K. Tamura, T. Hasegawa, K. Watanabe & M. Shimizu: Discrimination mechanism between class II tRNAs. The translational Apparatus, pp45, Berline, Oct 31-Nov 5 (1992).

M. Shimizu, H. Asahara, K. Tamura, T. Hasegawa & Himeno H.: Role of anticodon and discriminator in tRNA identity. 14th International tRNA workshop, pp61, Rydzyna, Poland, May 4-9 (1991).

Hasegawa, T., Miyano, M., Himeno, H., Kimura, K. & Shimizu, M.: Role of anticodon in the aminoacylation activity of E. coli tRNAThr. 14th International tRNA workshop, pp151, Rydzyna, Poland, May 4-9 (1991).

Himeno, H., Asahara, K. Tamura, T. Hasegawa, T. Ueda, T., Watanabe, K. & Shimizu, M. 14th International tRNA workshop, pp154, Rydzyna, Poland, May 4-9 (1991).